L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE

Name	L-glutamic acid gamma-(P-nitroanilide)*hydrochlor
Synonyms	H-GLU(PNA)-OH HCL N-(4-nitrophenyl)-L-glutamine hydrochloride GAMMA-L-Glutamyl-4-nitroanilide hydrochloride L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE L-Glutamic acid g-(p-nitroanilide) hydrochloride l-glutamic acid γ-(p-nitroanilide) hydrochloride L-glutamic acid gamma-(P-nitroanilide)*hydrochlor L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE N-(4-amino-1-carboxy-4-oxobutyl)-4-nitroanilinium chloride
CAS	67953-08-6
EINECS	267-944-5
InChI	InChI=1/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H/t9-;/m0./s1

Molecular Formula	C11H14ClN3O5
Molar Mass	303.7
Boling Point	590.6°C at 760 mmHg
Flash Point	311°C
Solubility	Soluble in Water (up to 5 mg/ml).
Vapor Presure	8.57E-15mmHg at 25°C
Appearance	solid
Color	Off-white
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
MDL	MFCD00039054

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
biological activity	GPNA (l-gamma-glutaml-p-nitroanilide) is a potent glutamine (Gln) transporter ASCT2(SLC1A5) the Ki of the selective inhibitor was 55 µm.
Target	Value
ASCT2 (Cell-free assay)	55 μM(Ki)
Cell Line:	A549 cells
Concentration:	10, 100, 250, 500 , and 1000 μM
Incubation Time:	48 hours
Result:	Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM.